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KMID : 0352119930090020135
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Journal of Kyung Hee University
1993 Volume.9 No. 2 p.135 ~ p.139
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Antithrombogenicity of New Heparin Immobilized Vascular Graft
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Abstract
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Synthetic and biosynthetic vascular grafts of small diameter (below 4 mm internal diameter) have long been considered to be prone to thrombosis, ultimately leading to the complete graft occlusion. As a novel approach to nonthrombogenic polymer
surfaces,
poly (ethylene oxide)-heparin grafted Biomer copolymer (B-PEOHEP). which can be coated onto surfaces without changing bulk properties, was developed and evaluated in canine models.
Arterial grafts of 4 mm internal diameter were fabricated with 20% Biomer, coated with the test material and grafted end-to-end in the carotid and femoral arteries of 10 dogs. B-PEO-HEP grafts were patent up to three days while control grafts
occluded
earlier. Rediolabeled platelet adhesion studies showed less adhered platelets on B-PEO-HEP surfaces than on control.
Explanted graft surfaces analyzed by scanning electrom microscopy showed relatively clean B-PEOHEP surfaces compared to controls. These observations suggest that Biomer modified with B PEO-HEP can provide a less thrombogenic surface.
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KEYWORD
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